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Warady, B

It's effective for skin-specific benefits but not for systemic anti-inflammatory or gene-modulation effects

Hence, instead of appearing over broader areas, freckles appear as spots

The Sulfur transfer pathway plays a role in the maintenance of redox homeostasis and oxidative stress, mainly due to the upregulation of intracellular Cys, GSH, and GSSG and the inhibition of ROS as a result of Cys-tRNA synthetase (CARS) deficiency (Floros et al., 2022