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Constipation management GLP-1 medications slow motility throughout the gut, not just gastric emptying
The effect is most noticeable when you first start and after each dose increase, then settles over time
The outer thigh (vastus lateralis) provides an alternative site with comparable absorption kinetics
This can help with blood glucose levels
Consider reducing sulfonylurea doses when starting semaglutide, particularly in patients with baseline A1c values below 8%
In db/db mice, the combined treatment of PYY and GLP-1 significantly enhanced systemic glucose treatment and liver glycogen synthesis with insulin stimulation (107)
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