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GIP and GLP-1 receptors can undergo desensitization when exposed to sustained high concentrations of their agonists

Does Not Contain: Wheat, gluten, corn, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives

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LEADER (liraglutide) [44], SUSTAIN-6 (semaglutide) [67], and REWIND (dulaglutide) [70] study showed beneficial renal outcomes, mainly reducing the occurrence of proteinuria

Common initial side effects include nausea, diarrhea, and vomiting

These effects are statistically significant but clinically modest