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Proc Natl Acad Sci U S A (2009) 106:128590

But these drugs also come with risks that shouldn't be overlooked, researchers warn in a study published Jan

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Pro-inflammatory cytokines, including IL-1 and IL-6, can impair brain development by disrupting synaptic plasticity, synaptogenesis, and neurotransmitter regulation (Khairova et al., 2009

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Why breakouts happen: Primarily due to "purging" (toxin release), hormonal shifts, or sensitivity to specific formulations