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Research suggests complementary mechanisms provide broader pathway coverage

Efficacy and safety of co-administered once-weekly cagrilintide 2.4 mg with once-weekly GLP1 2.4 mg in type 2 diabetes: A multicentre, randomised, double-blind, active-controlled, phase 2 trial

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Stem Cell Rev Rep 2025;21:182234

The mechanisms dont overlap, so theres no receptor competition

Addressing these challenges will require interdisciplinary approaches and sustained efforts to optimize the properties of NDBs and streamline their development pipeline for clinical use (Arciola et al., 2018