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GLP-1R plays a critical role in the signaling cascades leading to insulin release in response to an increase in blood glucose levels

In addition to suppressing appetite, boosting insulin secretion and slowing stomach emptying, these drugs appear to influence brain pathways involved in food reward and cravings, making them a potential candidate for tackling the loss of control that characterizes binge eating

Li X, Schuler MA, Berenbaum MR

Initial dosing typically begins at 2.5 mg once weekly for four weeks as a treatment initiation dose to improve gastrointestinal tolerability