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Antioxidants prevent this damage by directly neutralizing reactive oxygen species (ROS) by scavenging or indirectly by augmenting natural defense mechanisms

10.1016/j.apsusc.2005.02.064

Ferroptotic propagation: from single-cell execution to tissue-scale death programs

To exclude any effects associated with the procedure used for generation of a new monoclonal sub-clone, wild-type HepG2 cells were treated with varying concentrations of NFT or DEM for 24 h, fixed, and subjected to immunocytochemistry to visualize Nrf2 localization (Fig