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Kos, J.L

Depression of food intake induced in healthy subjects by glucagon

1 This capital infusion is primarily directed toward building production capacity for orforglipron, the companys highly anticipated experimental oral non-peptide glucagon-like peptide-1 (GLP-1) receptor agonist intended for the treatment of type 2 diabetes and obesity

Also acts as a reagent in the synthesis of reversible -ketoheterocycle inhibitors of fatty acid amide hydrolase as potnetial analgesics

Purpose: First meaningful escalation

While the impact of GLP-1 RAs on cardiovascular outcomes has been shown to be directly correlated with the reduction in A1c, these agents exhibit pleiotropic effects [54]