This is most relevant at the thigh and abdomen in lean patients
Our quantitative analyses show that: (1) while Sirt1, 2, 3, 6, and 7 preferentially remove hydrophobic acyl groups over the malonyl group (acyl group-selectivity between hydrophobic versus anionic acyl groups)
Albin N, Massaad L, Toussaint C, Mathieu MC, Morizet J, Parise O et al
In a cosmetic context, Abdulghani et al
But side effects are very under-reported. About half of adults who start GLP-1s stop within a year some because their insurance coverage changes with many reporting gastrointestinal side effects as a contributor
Second, the mechanistic analysis was not performed to explain why removing senescent cells did not result in more cartilage formation