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The viral S-protein and the ORF9b subunits could alter human cardiomyocyte metabolism and significantly impair the contractile function of the heart 119
However, its clinical utility is limited by safety concerns linked to prolonged benzodiazepine exposurespanning cognitive effects, falls and fractures, physiologic dependence, pneumonia, and respiratory complicationswith particularly heightened vulnerability in older adults and those with sleep-disordered breathing, and with long-term use associated with increased all-cause mortality 27,28,29,30,31
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No significant differences in hematological or serum biochemical parameters were observed between any treatment group and the control group (Additional file 2: Tables S8S9)
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