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[41,42] Here's the thing, however

ROS Scavenging and Gene Regulation: Oxidative stress upregulates the Microphthalmia-associated Transcription Factor (MITF), which acts as the primary on-switch for melanin production [5]

Huang K, ONeill KL, Li J et al (2019) BH3-only proteins target BCL-xL/MCL-1, not BAX/BAK, to initiate apoptosis
PubMed Central , Human Molecular Genetics , vol

Clarifying compoundgut microbiota interactions and whether microbial metabolism enhances or limits therapeutic efficacy would strengthen the gutliver axis perspective

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