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While semaglutide does not directly affect thyroid function in most patients, the FDA label includes a boxed warning regarding thyroid C-cell tumors observed in rodent studies, and semaglutide is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

Glucagon-like peptide-1 receptor agonist based medications (GLP-1s) have transformed the treatment landscape for type 2 diabetes and obesity over the past decade ( 1 , 2 )