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Each ingredient works through a different pathway smooth muscle relaxation (papaverine), sympathetic blockade (phentolamine), and direct vasodilation with cGMP stimulation (prostaglandin E1)

It helps control blood sugar levels by mimicking the GLP-1 hormone your body naturally produces

In a phase 2 trial in participants with obesity and MASLD, once-weekly treatment with the GIP/GLP-1/GCG triple agonist retatrutide resulted in substantial reductions in liver fat, body weight, abdominal visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (ASAT), serum lipids

[1] Importantly, Zepbound is not recommended for patients with severe gastrointestinal disease, including severe gastroparesis

Analyses were conducted using available values within the TriNetX platform, and patients with missing covariates were excluded from the relevant variable-specific analyses