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This was exemplified here by the fact that increased GSH production in the presence of 5-FOA (counter-selective for URA3 expression) appeared to be a non-specific response to 5-FOA, evident also in the control strain expressing URA3 behind pURA3 , rather than selection based on phenotypic heterogeneity as intended in this proof-of-principle study

Tomas FM, Knowles SE, Owens PC, Chandler CS, Francis GL, Read LC, Ballard FJ

Twenty key molecular drivers involved in proteolysis and angiogenesis have been identified as potential biomarkers and therapeutic targets

Here's why

10.1016/j.apmr.2016.09.124 Arch