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Compared with other forms of carnitine, PLC exhibits a special affinity for muscle tissues, including those of the heart and skeletal muscles.* GPLC is a powerful antioxidant that scavenges free radicalsprotecting against lipid peroxidationassists in energy productioncontributing to proper carbohydrate metabolism, improved muscle function, and reduced lactic acid buildup during low-oxygen conditions, such as exerciseand provides powerful support for peripheral arterial blood flow
Eight healthy volunteers were given a calorie-restricted diet with either oral MK-677 or a placebo for two 14-day periods
The dose response extends beyond weight loss to metabolic parameters
It makes the body more efficient in burning fat as fuel, including liver fat
Among all medications used for weight loss, the most commonly reported side effects are nausea and constipation, but irreversible gallbladder and pancreatic disease is also reported
The study, which tested the drug in 529 patients with obesity and heart failure with preserved ejection fraction (HFpEF), demonstrated a 16.6-point increase at 52 weeks, with regard to the Clinical Summary Score (CSS) on the Kansas City Cardiomyopathy Questionnaire (KCCQ) a measure of symptoms of heart failure in comparison to an 8.7-point increase in the placebo group
