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Obesity and insulin resistance sustain elevated circulating concentrations of pro-inflammatory cytokines including Tumour Necrosis Factor-alpha (TNF-), Interleukin-1 (IL-1), and Interleukin-6 (IL-6) molecules that promote DNA damage, tumour angiogenesis, and immune evasion

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Our results frame a model in which EBV infection contributes to ferroptosis evasion and re-establishment of redox homeostasis by upregulating GPX4 expression, facilitating the development of chemoresistance in NPC (Fig

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