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Deficiencies in other micronutrients, including vitamin B 6 , vitamin B 12 , and omega-3 fatty acids, have been linked to depression, and vitamin D deficiency has also been associated with negative effects on mood (51, 144)

Patients with certain variants may show higher baseline inflammatory markers or slower adaptation to rapid metabolic change

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It also interferes with the ability of the liver to store and activate eminent nutrients like B vitamins

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