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Moreover, GLP-1RA reduced the risk of MACE by 14% in the overall diabetic population, with an apparent greater effect in patients with established CV disease (16% vs 6% reduction, respectively), although the lack of significant interaction between subgroups does not allow to separate them [12]

Despite the significant advances in understanding the immune-inflammatory mechanisms of varicocele summarized in this review, several critical knowledge gaps and challenges remain to be addressed

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