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Immunofluorescence staining and western blot results verified that GPX1 expression was absent in the cochlear SGNs of gpx1 / mice (Supplementary Figures 1A,C), and there was no significant difference in SGNs number between the gpx1 / mice and WT mice (Supplementary Figure 1B), which indicated that the absence of GPX1 in normal SGNs would not affect the survival of SGNs

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Indeed, it was clearly shown that the antioxidant N-acetyl-L-cysteine (NAC) can inhibit eryptosis in vitro [116] and significantly prolong the half-life of circulating mouse erythrocytes in vivo [72] presumably by interfering with efferocytosis of eryptotic cells

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