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Aggressive hydration before, during, and after drinking helps, as does eating substantial food

Pica behavior is a validated endpoint to assess the ability of a compound to induce nausea/malaise in non-vomiting species, as mouse, based on the monitoring of non-nutritive (kaolin) food intake, as an index of gastrointestinal discomfort 43,44

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If you have heart or kidney disease with fluid restrictions, consult your healthcare provider about appropriate hydration targets

The typical starting dose of semaglutide is 0.25 mg weekly

25 Research shows that obesity treatment paradigms that do not incorporate medications are minimally successful, with patients achieving a modest 5% to 7% total weight loss