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Sub-chronically, 0839 and 0833 had comparable small and transient reducing effects on food intake and body weight in DIO mice, with similar additional add-on effects on top of semaglutide

Target: upper-normal range for age, not supraphysiological Quarterly monitoring: IGF-1, fasting glucose, HbA1c

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reported that depression aggravates hepatic steatosis in mice and contributes to NAFLD progression by stimulating the HPA axis (280)

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