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Alternative pharmacological options for managing type 2 diabetes and insulin resistance include: Metformin : Remains the first-line medication for type 2 diabetes, improving hepatic insulin sensitivity and reducing hepatic glucose production SGLT2 inhibitors : Promote glucose excretion through the kidneys and offer cardiovascular and renal protection Single-receptor GLP-1 agonists : Such as semaglutide, dulaglutide, or liraglutide Pioglitazone : A thiazolidinedione that directly improves insulin sensitivity, though weight gain and fluid retention limit its use For patients with non-diabetic hyperglycaemia (NDH), lifestyle modification remains the primary intervention

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More specifically, semaglutide works by acting like a natural hormone in your body called GLP-1

Gastroenterology 150 , 11471159.e5 (2016)