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Hasan and Banerjee, 2020

Some studies suggest GLP-1 activation reduces inflammatory cytokine secretion from immune cells independent of weight loss, but human evidence remains limited outside diabetes and cardiovascular contexts

Sulphonylureas (e.g., gliclazide): these stimulate insulin release but carry a risk of hypoglycaemia and weight gain, requiring education and monitoring

Losing mostly fat is the goal

Future directions should prioritize single-cell multi-omics, immune-tumor co-modeling, and real-time clinical feedback systems to unlock the full potential of organoid-informed metabolic therapy in CRC

Liraglutide and semaglutide were the most frequently investigated GLP-1RAs