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20.4% CagriSema Trial REDEFINE 2 (NEJM 2025) Duration 68 weeks Population T2D + BMI 27 (n=1,206) Mean Weight Loss 13.7% CagriSema vs 3.4% placebo
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By day 3-4 of multi-dose use, microbial contamination becomes likely
It contains a cyano (cyanide) group in its structure, which makes it more stable than other forms of vitamin B12 as the cyanide stabilizes the molecule from deterioration
Plasma concentrations decline with age - from approximately 200 ng/mL at age 20 to under 80 ng/mL by age 60
It does not provide human subcutaneous exposure data
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