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Assessment of risk of bias Due to the great disparity in study designs (clinical and basic research) available for each candidate biomarkers of interest, we did not use ROC curve analysis as a selection criterion to address robustness, but instead included the presence of at least one study per biological compartment including at least 30 individuals per group as a mandatory criterion

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10.1212/WNL.0b013e318221acd3 Neurology 152 ShinJ

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