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Their nonspecific distribution also causes toxicity in organs such as liver, kidneys, lungs, and heart (van Erven and Schalij 2010)
doi: 10.1089/thy.2021.0142 12 SemmlerAMundorfAKKuechlerASSchulze-BosseKHeideckeHSchulze-ForsterKet al
Oxidative stress and obesity: the chicken or the egg
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An international panel of experts determined that berberine may be helpful in patients with mild cases of high cholesterol who do not tolerate statin drugs or who have metabolic syndrome
Theres only one phase one trial thats registered right now, and its been registered since 2016, and nothing has been updated on that registration, so that tells you something as well
