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Gene delivery In vitro and in vivo studies have proven the efficacy of IGF-1 gene therapy in OA treatment [16, 60, 61]
A diet alone may be insufficient in maintaining levels of each throughout the body
[5] That finding should not be expanded into a universal claim that AOD9604 directly activates CPT1, increases mitochondrial number, induces oxidative gene expression, or increases fatty-acid oxidation in every tissue or model
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Furthermore, a critical appraisal of the cited evidence reveals recurrent limitations
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