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Vitamin C and glutathione incompatibility lead to instability

In addition to the PERK-ATF4-CHOP axis, other key ER stress pathways, such as IRE1/XBP1 and ATF6 also contribute to the UPR, collectively managing protein misfolding and restoring homeostasis, or, if stress persists, trigger cell death ( Various studies targeting ER stress signaling pathways and components of the UPR have demonstrated that CHAC1 expression is upregulated downstream of the ATF4-dependent signaling pathway (Figure 4)

[Abstract] Representative zebrafish embryo xenograft images before (Day1) and after 48h (Day3) of treatment and corresponding waterfall plots representing the change from baseline growth of individual NB-S-124 zebrafish embryo neuroblastoma xenografts treated with DMSO (blue), Isotretinoin (500 nM) (red), navitoclax (10 M) (green), and combination (yellow) for 48 h

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doi: 10.1016/j.bbrc.2019.08.092 193 HouCWangDZhangL

Investigacion Clinica, 59(3), 230-241