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NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis
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This master antioxidant is the first line of defense against oxidative stress and cellular damage
In contrast, GLP-1RAs are designed to resist degradation by DPP-4, enabling sustained high plasma concentrations and prolonged systemic effects
Importantly, the heterologous expression of SsCm1 into yeast aro7 mutant could not restore the ability of yeast to synthesize tyrosine and phenylalanine (Fig
