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This is denoted by the lower right quadrant of the eDISH plot

Castrillon F et al

Risk of cancer in patients treated with recombinant human growth hormone in childhood

Regular monitoring and adjustments ensure optimal results for each individual

PMID 2880477

For example, in hereditary leiomyomatosis and renal cell cancer (HLRCC), a high level of fumarate caused by genetic mutation of fumarate hydratase induces the succination of Kelch-like ECH-associated protein 1 (KEAP1) accompanied by the consumption of a fumarate molecule 134,135