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9 A Counterintuitive Finding Worth Knowing A May 2026 retrospective analysis presented at Digestive Disease Week by Thomas Fredrick, MD., of the Mayo Clinic, found that participants on semaglutide who experienced constipation had 14.4% total body weight loss at 12 months, compared to 10.8% in those without constipation

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Keeping an eye on it and talking to a doctor can help figure out what to do

Labs can support broad review but may not capture local tissue or gut response

345,346 GLP-1 may also reduce the expression of cartilage-degrading enzymes by inhibiting the MAPK pathway or activating anti-inflammatory pathways such as PI3K/Akt, thereby alleviating cartilage damage

High salt intake increases plasma trimethylamine N-oxide (TMAO) concentration and produces gut dysbiosis in rats