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On an empty stomach , because dietary fat and the insulin/glucose rise after a meal blunt the GH pulse
Although most semaglutide and tirzepatide side effects are not dangerous, both medicines can cause rare but serious problems
Optimal injection timing is upon waking and 3060 minutes before bed to align with natural growth hormone pulse windows during cortisol awakening response and slow-wave sleep
However, most insurance companies dont cover compounded semaglutide, especially for weight loss, leaving many to pay potentially high out-of-pocket costs
JAMA 282:15681575 Clemmensen C, Chabenne J, Finan B et al (2014) GLP-1/glucagon coagonism restores leptin responsiveness in obese mice chronically maintained on an obesogenic diet
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