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Appetite and food reward 3-arm Phase 1 tirzepatide vs liraglutide 3.0 mg vs placebo: measured lunch intake fell 524.6 kcal vs placebo by week 3 (about 72% of that difference remained at week 6), with craving and hedonic-hunger reductions exceeding liraglutide

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Although potential involvement of 3UTR cannot be excluded, we demonstrated that YBX1, which facilitates 5UTR-mediated HIF1A translation 38,46 , directly binds to the PRKAA1 5UTR and dictates AMPK1 protein synthesis

[PMID: 42278509] PubMed record related to this compound for laboratory literature review

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