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In this regard, GLP-1R agonists (i.e., exenatide) improve insulin resistance suppressing pro-inflammatory phenotypes of monocytes/macrophages, and directly modulating NF-B activation and IL-1, IL-6, and TNF- expression (Yu et al., 2019)

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Close monitoring with clinical review and repeat vitamin B12 levels are required on a monthly basis to review symptoms and ensure normalization of B12 deficiency