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Title: Structural insights into ligand recognition and activation of the melanocortin-4 receptor Authors: Huibing Zhang, Li-Nan Chen, Dehua Yang, Chunyou Mao, Qingya Shen, Wenbo Feng, Dan-Dan Shen, Antao Dai, Shanshan Xie, Yan Zhou, Jiao Qin, Jin-Peng Sun, Daniel H
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Patients often report initial gastrointestinal side effects, such as nausea and vomiting, which can be distressing and sometimes lead to discontinuation of the drug
In the STEP trials, participants lost an average of 15-20% of their body weight over 68 weeks, higher than other weight loss medications