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The rationale for adding it to tirzepatide is that calorie restriction and GI side effects from GLP-1 medications can reduce B12 absorption, potentially leading to deficiency over time
GLP-1s may offer a dual benefit for patients with chronic conditions like diabetes or obesity who are also struggling with a substance use disorder: one medication can treat both conditions at once, Al-Aly said
Thyroid Tumor Risk Mounjaro carries a boxed warning from the FDA about the possible risk of thyroid cancer, often referred to as thyroid cancer Mounjaro. The active ingredient, tirzepatide, has been shown in animal studies to cause thyroid tumors in rodents, but it is not known if this increased risk applies to humans
The side effects of Mounjaro are transient, meaning they typically occur at the start of treatment and during dose escalation, then decrease over time
Just last week, Lilly revealed new phase 2 findings for oral orforglipron that show it can induce clinically meaningful weight reductions in overweight or obese adults