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Key Differences: Metformin stands out as the preferred first-line therapy for most newly diagnosed patients, largely due to its extensive research background and lower cost, as generic versions are readily available [17]

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Furthermore, alcohol itself is a gastric irritant that can cause nausea, vomiting, and gastrointestinal discomfort even in healthy individuals

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For example, chronic low-grade inflammation, or "inflammaging," exacerbates tissue damage and is modulated by NAD+-dependent enzymes