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Mechanism of -galactosidase-cleavable linkers in ADCs A representative implementation of -galactosidase-responsive linkers was reported by Kolodych and coworkers, who developed trastuzumabMMAE ADCs incorporating a galactoside trigger and a self-immolative release module
Even the best-designed capsule has its limits
Timper K, del Ro-Martn A, Cremer AL, Bremser S, Alber J, Giavalisco P, et al
Precursor-directed immune-mediated anemia Dogs and cats with precursor-directed immune-mediated anemia (PIMA, also called non-regenerative immune-mediated anemia) usually present with severe normocytic normochromic anemia (Hcts, 20% cells with bound IgG) in low numbers of dogs (5/17, 29%) and a similar number of precursors were expressing phosphatidylserine (20-80% of cells)
The role of IL-17 in systemic autoinflammatory diseases: mechanisms and therapeutic perspectives
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