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There is a strong bidirectional regulatory relationship between the inflammatory response and oxidative stress: pro-inflammatory factors such as TNF- and IL-1 can promote further ROS bursts by activating the NADPH oxidase and xanthine oxidase systems

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Co-incidence of elevated IL-6 and lower GSH levels was previously reported (Valles et al., 2013), while obesogenic diets were shown to induce both of these effects in mice (Han et al., 2017) and rats (Govindaraj and Sorimuthu Pillai, 2015)