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FDA Approved Weight Loss Medications orlistat (Xenical/Alli) phentermine-topiramate (Qsymia) naltrexone-bupropion (Contrave) liraglutide (Saxenda) semaglutide (Wegovy) setmelanotide (IMCIVREE) Experts explain that the increasing recognition that diet and exercise alone are unlikely to result in sustained weight loss had led to renewed interest in medication to supplement lifestyle changes