doi: 10.1080/19390211.2023.2301366 73
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Skin lightening with the use of glutathione occurs because this compound can change eumelanin (dark pigment) into pheomelanin (two true pigments of light)
The elevated homocysteine could be more related to folate deficiency than B12, so you cant use it as an exclusive marker for B12 deficiency
Psychiatry 87 , 1521 (2020)
Several recent studies have pointed out that alterations of the gut microbial tryptophan metabolism influence peripheral Trp availability, affecting central tryptophan levels and, thereby, leading to changes in the central serotonin metabolism (171, 172)