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Localized wound healing studies typically use every-48-hour dosing for 1421 days, while systemic collagen synthesis protocols use every-72-hour dosing for 2128 days
The copper coordination chemistry of GHK-Cu enables controlled cellular copper delivery while preventing the formation of reactive oxygen species characteristic of free copper toxicity, with the peptide's binding affinity (log K = 16.1) positioning it perfectly within the physiological copper transport hierarchy to facilitate controlled metal transfer to enzymatic targets including lysyl oxidase (essential for collagen cross-linking) and superoxide dismutase (critical for antioxidant defense)
About the Authors Medically reviewed by Phyllis J
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