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For more details regarding LoCITT, including how to participate in this or subsequent trials, please visit The study team will host a webinar on November 5, 2025, 11 a.m

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Despite the benefits of GLP-1 receptor agonists, affordability and insurance coverage limitations remain critical barriers in some regions, which could potentially hinder widespread adoption

GLP-1 Receptor Agonists and NAION: What Clinicians Should Know As GLP-1 receptor agonists (GLP-1 RAs) like semaglutide, liraglutide, and tirzepatide gain prominence in managing diabetes and obesity, its crucial we remain vigilant about rare but significant adverse events

GLP-1 RAs Hold Promising Potential for Reduction of Cardiometabolic Risk Factors additional benefits : Brain: Appetite suppression, nerve protection, and decreased neuroinflammation Heart: Decreased blood pressure (systolic and diastolic), reduced total cholesterol levels, lowered endothelial dysfunction, and increased heart rate Liver: Decreased glucose production Pancreas: Increased insulin secretion, decreased glucagon secretion, B islet cell proliferation GI Tract: Decreased gastric emptying Because these drugs cause weight loss, it is not clear whether the GLP-1 RAs or the weight loss reduces cardiometabolic risks

For patients seeking physician-supervised GLP-1 therapy through a fully online model, the review ultimately recommended CoreAge Rx as the top choice among providers evaluated in 2026