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The pCNFRS-TSDV was then applied to construct the nanobodies with pAcF incorporated at different sites
The extract displayed dose- and time-dependent antiproliferative effects on A549 cells, with IC 50 decreasing from 340.63 g/mL at 24 h to 107.08 g/mL at 72 h, indicating enhanced cytotoxicity over time
PMC 12155999
If additional glycemic control is needed, the dose can be further increased to 1 mg and 2 mg once weekly
This makes it especially suitable when peptides are used over weeks rather than a single session
Eur J Med Chem 166:502513
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