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[2] However, elevated MMA is not conclusive, as it is seen in people with B 12 deficiency, but also in elderly people who have renal insufficiency, [28] and elevated homocysteine is not conclusive, as it is also seen in people with folate deficiency

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The net effect studied in adipocytes is a higher NAD+/SAM pool that shifts the cell toward increased energy expenditure rather than fat storage

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