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GLP-1 AND GIP Given the extensive clinical experience with GLP-1 RAs and the established safety profile in cardiovascular disease settings, peptide multi-agonists have been developed to target multihormonal peptide-secreting enteroendocrine cells.8 Due to their glucose-lowering functions, the combination of GLP-1 and GIP hormones is one of the most attractive strategies for treating T2DM.8, 9 GLP-1 was first identified as a cleavage product of preproglucagon generated by L cells in the small intestine and functions to increase postprandial insulin production and lower blood glucose.10, 11, 12, 13 Since its discovery, efforts have focused on extending GLP-1 agonist activity through structural changes.14 Liraglutide and semaglutide, two long-acting GLP-1 RAs, have been authorized for the treatment of T2DM and obesity
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This correlation does not tell us whether the symptom improvement was driven by weight loss, direct anti-inflammatory effects, or both, but it confirms that the metabolic improvements tracked alongside the symptom improvements
As well as lifestyle changes, medications may be used to treat diabetes
Safety of Compounded Medications
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