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The landmark PANTHEON trial, a 1-year multicenter RCT in 1,006 Chinese COPD patients, found that high-dose NAC (600 mg twice daily) reduced the rate of acute exacerbations by 22% compared to placebo (1.16 vs 1.49 exacerbations per year, p=0.0011) (Zheng et al., Lancet Respir Med, 2014) [44]

Elucidation of the molecular mechanisms underlying sorafenib-induced hepatotoxicity

While NAC is generally considered safe and well-tolerated, some individuals should avoid it, including: People with asthma (NAC may trigger bronchospasm)

We therefore used female animals in our study

Missing one or two days in a cycle will not significantly affect outcomes

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