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Although both produce clinically meaningful results

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LRRK2 promotes TH expression and increases DA generation which can be aggravated by LRRK2 mutations, while WT PINK1 suppresses TH expression and DA generation, which can be abrogated by PD-linked PINK1 mutations [44]

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Exendin-3 (GLP-1 blocker), LY2409021 (GCG blocker), YM-254890 (Gq blocker), MDL-12330A (adenylate cyclase blocker), calphostin C (protein kinase C [PKC] blocker) and TPPO (TRPM5 blocker) were used as specific inhibitors

"The weight just kept piling on," she said