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The presence of non-responders to GLP-1R therapy continues to complicate treatment outcomes, underscoring the need for a deeper understanding of individual variability in response [117,118]

Additionally, developing novel efficacy endpoints beyond conventional CAP, such as evaluating the specific modulation of hepatic triglyceride compositionparticularly the proportion of lipotoxic saturated fatty acidsmay more directly elucidate the mechanisms underlying its hepatoprotective effects

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[22] Peptides with pharmacological activity intended for human use including growth hormone secretagogues are likely to be classified as POMs by default if they were licensed, and their unlicensed supply for human use is therefore unlawful

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