Apovian, M.D., co-director of the Center for Weight Management and Wellness at Brigham and Women's Hospital, points out that its tough to compare these trials because they may have differences like how long the subjects are on the drugs
A 2023 analysis of the SUSTAIN and PIONEER trials published in Cardiovascular Diabetology showed significant reductions in high-sensitivity C-reactive protein, a marker of systemic inflammation, among patients taking semaglutide
This same principle applies to other next-generation metabolic peptides like Survodutide and Mazdutide
But glucagon has a second, metabolically important function: it increases energy expenditure by stimulating the breakdown of stored fat (lipolysis) and promoting thermogenesis heat production from metabolic activity
doi: 10.1136/gutjnl-2021-324243 63
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